Cymbalta has been like a miracle drug for me. I have been on various antidepressants and tranquilizers on and off (mostly on) since my late 20s and am now 63. Before Cymbalta I was on Prozac for several years. Prozac was helpful but I woke up every morning having anxiety for several hours. After taking my first Cymbalta in the morning, the next morning I woke up without the anxiety and have been anxiety free for a month now. I can hardly believe it!